EXAMINE THIS REPORT ON SODIUM PENTOBARBITAL SDS

pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Coadministration of CYP3A4 inducers may possibly decrease sufentanil degrees and efficacy, probably precipitating withdrawal syndrome in individuals who definitely have developed physical dependence to sufentanil.